GS-441524 is a plasma metabolite of the antiviral prodrug remdesivir that has a half-life of 24 hours in humans. It has been found to be effective in fighting off feline coronavirus strains, responsible for the lethal disease feline infectious peritonitis (FIP), in in vitro tests.
FIP is caused by an immune defect or deficiency which causes white blood cells to replicate the virus as opposed to fighting it. Those cats whose immune system is not able to fight the virus, develop into wet FIP, while those who have a partial immune response develop dry FIP.
GS441524 is a nucleoside analog that acts as an alternative substrate and chain terminator. In simple terms, it interrupts the chain reaction of the virus, stopping its replication. This powerful nucleoside is proving to be a promising drug in combating this deadly infection in cats.
| Appearance | Tablets |
| GS Standard | 99.5%min |
| Content | 20mg, 40mg, 50mg and 60mg |
| Application | For CAT FIP R&D Use ONLY |
| Recommended dosage | 10 mg/kg |
Feline Infectious Peritonitis (FIP) is a complex and challenging disease to diagnose accurately. It is caused by a mutated strain of feline coronavirus (FCoV), and while many cats are exposed to FCoV, only a small percentage develop FIP. The disease can manifest in two main forms: wet (effusive) and dry (non-effusive).
Key Steps in Diagnosing FIP:
1. Clinical Signs
Wet FIP: Abdominal or chest fluid accumulation, breathing difficulty, fever, weight loss, loss of appetite, lethargy.
Dry FIP: Neurological signs, eye inflammation, organ enlargement, jaundice, chronic fever.
2. Blood Tests
Elevated total protein, especially globulins
Low albumin-to-globulin (A:G) ratio (<0.5 is highly suspicious)
Non-regenerative anemia
Elevated liver enzymes and bilirubin
Lymphopenia and neutrophilia
3. Fluid Analysis (for wet FIP)
Straw-colored, sticky fluid with high protein (>3.5 g/dL)
Low cellularity
Rivalta test: A quick screening test often used in clinics; a positive result supports FIP diagnosis.
4. Imaging (Ultrasound/X-ray)
May show fluid in the abdomen or chest
Enlarged lymph nodes or organs
Brain or spinal cord involvement in neurological cases
5. PCR Testing
Detects viral RNA in blood, tissue, or effusion
A positive result in body fluid, especially with clinical signs, strongly supports diagnosis
6. Definitive Diagnosis
Biopsy with immunohistochemistry (IHC) or PCR from affected tissues is considered the gold standard but is invasive.
Recommended dosage: 10mg/KG * body weight kg
Taking time: Both taken before and after meals is ok. It is recommended to take it at a fixed time every day.
Taking method: Take it directly. If the cat does not eat it, it can also be mixed in the feed.
Storage: Store at room temperature or Store at 2~4 ° C. Avoid light. Shelf life is one year.
Recommended treatment for 12 weeks.
