GS-441524 is the main plasma metabolite of the antiviral prodrug remdesivir, and has a half-life of around 24 hours in human patients. Remdesivir and GS-441524 were both found to be effective in vitro against feline coronavirus strains responsible for feline infectious peritonitis (FIP), a lethal systemic disease affecting domestic cats.
If a cat’s immune system is healthy and mature, the white blood cells should fight off an infection or virus, and allow the cat to build up an immune response, or antibodies. Cats who develop FIP have an immune defect or deficiency that causes the white blood cells to replicate, rather than fight, the virus. Essentially, the cats immune system is spreading the virus throughout the cat’s body rather than trying to eliminate it. Cats who have no immune response develop wet FIP, while cats who have a partial immune response develop dry FIP.
The nucleoside analog GS441524 is a molecular precursor to a pharmacologically active nucleoside triphosphate molecule. These analogs act as an alternative substrate and RNA-chain terminator of viral RNA dependent RNA polymerase. In layman’s terms, GS441524 interjects itself into the chain reaction and stops the replication of the virus. In FIP, this action stops the spread of the virus to other cells, allowing for a complete immune response to occur.
- Product Name: GS441 FIP Treatment
- Molecular Weight: C12H13N5O4
- Product Form: Injections
- Specification: 20mg/mL, 5.5mL
- Product Usage: Cat FIPV Treatment
- CAS: 1191237-69-0
- Cat FIP: Yes
- Remdesivir intermediate: Yes
|Product Name||GS441 FIP Treatment|
|Product Shelf Life||1 Year|
|Product Storage||Store In A Cool, Dry Place|
|Product Packaging||10 Vial Per Box|
|Shipping Method||Air(UPS, FedEx, TNT, EMS) Or Sea|
|Test Method||HPLC UV|
|Specification||20mg/mL or 30mg/mL|
|Product Usage||Cat FIPV Treatment|
FIP in Cats Symptoms
The symptoms of FIP in cats can vary depending on the type of FIP. Wet FIP is the more common form and is characterized by fluid accumulation in the abdomen or chest. Symptoms of this form of FIP include weight loss, loss of appetite, vomiting, diarrhea, and difficulty breathing.
FIP Cats Treatment
FIP was once considered a death sentence for cats, however, hope has emerged for cats with FIP. With the availability of GS-441524 treatment, the prognosis for cats with FIP has greatly improved.
Packing: 1 box * 10 vials
Recommended treatment: 12 weeks.
Recommended dosage:*DOSAGE IS BASED ON THE WEIGHT AND SYMPTOMS*
Ascites / pleural effusion: 0.5mL/kg * body weight kg + 0.1 residue
FIP(Wet):0.4mL/kg * body weight kg + 0.1 residue
FIP(Dry): 0.6mL/kg * body weight kg + 0.1 residue
Eye / nerve entry: 0.7mL/kg * body weight kg + 0.1 residue
Recurrence: 0.9 mL/ kg * body weight kg + 0.1 residue