GS-441524 is an antiviral compound. GS-441524 is the primary active metabolite of Remdesivir and has shown significant effectiveness in treating certain viral infections, including feline infectious peritonitis (FIP), a disease caused by feline coronavirus in cats. It has gained attention primarily in veterinary medicine for this use.
GS-441524 works by inhibiting viral replication. It targets the viral RNA polymerase enzyme, interfering with the virus’s ability to copy its genetic material, thereby slowing or stopping the infection.
GS-441524 is most notable for treating feline infectious peritonitis (FIP), which was previously considered fatal in cats. The antiviral tablet form of GS-441524 has provided a breakthrough in the treatment of this condition, leading to remission in many cases.
| Appearance | Tablets |
| GS Standard | 99.5%min |
| Content | 20mg, 40mg, 50mg and 60mg |
| Application | For CAT FIP R&D Use ONLY |
| Recommended dosage | 10 mg/kg |
The diagnosis of Feline Infectious Peritonitis (FIP) can be challenging due to the lack of specific diagnostic tests and the similarity of its symptoms to other feline diseases. FIP is caused by a mutation of the feline coronavirus (FCoV) and comes in two main forms: wet (effusive) and dry (non-effusive). Diagnosing FIP typically involves a combination of clinical signs, laboratory tests, imaging, and, in some cases, biopsy or post-mortem analysis.
Recommended dosage: 10mg/KG * body weight kg
Taking time: Both taken before and after meals is ok. It is recommended to take it at a fixed time every day.
Taking method: Take it directly. If the cat does not eat it, it can also be mixed in the feed.
Storage: Store at room temperature or Store at 2~4 ° C. Avoid light. Shelf life is one year.
Recommended treatment for 12 weeks.
1. Introduction to the drug
Ingredients: GS441524 is a nucleoside analog that works by inhibiting viral RNA polymerase.
Indications: Mainly used to treat feline infectious peritonitis (FIP), especially wet and dry FIP.
2. Usage
Dosage: The dosage is usually calculated based on the cat's weight. The general recommended dose is 4-10 mg/kg per day. The specific dosage should be adjusted by the veterinarian based on the cat's condition and response.
Dosage frequency: Usually once a day for at least 12 weeks. Severe cases may require longer treatment.
Dosage: The tablets should be fed directly to the cat or mixed into a small amount of food to ensure that they are completely swallowed.
3. Side effects
Common side effects: May include symptoms such as loss of appetite, nausea, vomiting, and fatigue.
Serious side effects: Rare, but may include abnormal liver and kidney function. Regular blood tests are required to monitor the cat's health.
4. Precautions
Regular check-ups: During treatment, it is recommended to take the cat to the veterinarian for regular check-ups to ensure that the treatment is effective and no serious side effects occur.
Storage Conditions: The tablets should be stored in a dry, cool place away from direct sunlight and high temperatures.
