GS-441524 is the main plasma metabolite of the antiviral prodrug remdesivir, and has a half-life of around 24 hours in human patients. Remdesivir and GS-441524 were both found to be effective in vitro against feline coronavirus strains responsible for feline infectious peritonitis (FIP), a lethal systemic disease affecting domestic cats.
Cats with healthy and mature immune system are able to fight off a virus and build up an immune response, or antibodies. However, cats who suffer from FIP have an immune system that is not capable of fighting the virus, instead it spreads the virus throughout the body. Cats who have no immune response develop wet FIP, while cats with a partial immune response develop dry FIP.
The nucleoside analog GS441524 is a precursor to an active nucleoside triphosphate molecule, that acts as a substitution to the infectious virus. It injects itself into the chain reaction and stops the virus from replicating. Studies have shown that cats who were infected with FIP, and were given GS441524, had a decreased virus load, as well as a regression of clinical signs.
| Parameters | Details |
|---|---|
| Product Name | GS-441524 Injections |
| Route of Administration | Intramuscular Or Subcutaneous |
| Packaging | 10 Vial Per Box |
| Specification | 20mg/mL, 30mg/mL |
| Form | Injections |
| Active Ingredient | GS-441524 |
| Storage | Store At 2°C To 20°C |
| Shelf Life | 12 Months |
| Shipping Method | Air (UPS, FedEx, TNT, EMS) or Sea |
| CAS | 1191237-69-0 |
Packing: 1 box * 10 vials
Recommended treatment: 12 weeks.
Recommended dosage:*DOSAGE IS BASED ON THE WEIGHT AND SYMPTOMS*
Ascites / pleural effusion: 0.5mL/kg * body weight kg + 0.1 residue
FIP(Wet):0.4mL/kg * body weight kg + 0.1 residue
FIP(Dry): 0.6mL/kg * body weight kg + 0.1 residue
Eye / nerve entry: 0.7mL/kg * body weight kg + 0.1 residue
Recurrence: 0.9 mL/ kg * body weight kg + 0.1 residue
