GS-441524 is the principal metabolite of remdesivir, a prodrug with a half-life of approximately 24 hours in humans. Researchers have discovered that, both remdesivir and its metabolite GS-441524 are effective against the feline coronavirus strains causing the often fatal feline infectious peritonitis (FIP).
Under normal circumstances, white blood cells are integral in fighting off viruses and generating antibodies to prevent replication; however, cats with immune defects or deficiencies are unable to do this. Consequently, the coronavirus is able to replicate and spread into the cat's body causing either wet or dry types of FIP.
GS441524 works as an analog and carries out RNA dependent RNA polymerase, stopping the virus from replicating and allowing the immune system of the cat to destroy the virus before it does any harm.
Recommended treatment: 12 weeks.
Recommended dosage:*DOSAGE IS BASED ON THE WEIGHT AND SYMPTOMS*
Ascites / pleural effusion: 0.5mL/kg * body weight kg + 0.1 residue
FIP(Wet):0.4mL/kg * body weight kg + 0.1 residue
FIP(Dry): 0.6mL/kg * body weight kg + 0.1 residue
Eye / nerve entry: 0.7mL/kg * body weight kg + 0.1 residue
Recurrence: 0.9 mL/ kg * body weight kg + 0.1 residue
Storage
Store at room temperature or Store at 2~4 ° C (Better). Avoid light. Shelf life is one year.
Do not place in a sub-zero environment. Because this will result in the precipitation of active ingredients and the appearance of crystals, thus affecting the concentration and therapeutic effect.
