GS-441524 is the main plasma metabolite of the antiviral prodrug remdesivir, and has a half-life of around 24 hours in human patients. Remdesivir and GS-441524 were both found to be effective in vitro against feline coronavirus strains responsible for feline infectious peritonitis (FIP), a lethal systemic disease affecting domestic cats.
When a cat's immune system is functioning normally, white blood cells are able to fight off viruses and form antibodies to prevent it from replicating. However, cats who develop FIP are unable to do this due to an immune defect or deficiency. As a result, their white blood cells are unable to fight off the virus and allow for it to spread throughout the cat's body, leading to either wet or dry FIP.
To treat the virus, GS441524 acts as an analog which carries out a molecular process called RNA dependent RNA polymerase. In simpler terms, this process involves GS441524 inserting itself into the chain reaction and effectively halting the virus from replicating.
| Parameter | Value |
|---|---|
| Molecular Weight | C12H13N5O4 |
| Shipping Method | Air(UPS, FedEx, TNT, EMS) Or Sea |
| Specification | 20mg/tablets, 40mg/tablets, Or Customized |
| Product Usage | Cat FIPV Treatment |
| Product Name | GS441524 FIP Treatment |
| Product Packaging | 10 Tablets Per Bag |
| Test Method | HPLC UV |
| Product Shelf Life | 1 Years |
| Product Storage | Store In A Cool, Dry Place |
| Product Form | Tablets |
The dosage recommended for cats is 10mg per kilogram of body weight. It can be taken both before and after meals, and it is highly recommended to take it at the same time each day for the best results.
It can be taken directly, however if the cat does not consume it on its own, it can also be mixed in the food. For optimal effectiveness, it is recommended to take it for a period of 12 weeks.
