GS-441524 is the main plasma metabolite of the antiviral prodrug remdesivir, and has a half-life of around 24 hours in human patients. Remdesivir and GS-441524 were both found to be effective in vitro against feline coronavirus strains responsible for feline infectious peritonitis (FIP), a lethal systemic disease affecting domestic cats.
When a cat's immune system is functioning normally, white blood cells are able to fight off viruses and form antibodies to prevent it from replicating. However, cats who develop FIP are unable to do this due to an immune defect or deficiency. As a result, their white blood cells are unable to fight off the virus and allow for it to spread throughout the cat's body, leading to either wet or dry FIP.
GS441524 acts as an analog which carries out a molecular process called RNA dependent RNA polymerase. In simpler terms, this process involves GS441524 inserting itself into the chain reaction and effectively halting the virus from replicating.
| Property | Description |
|---|---|
| Molecular Formula | C12H13N5O4 |
| CAS Number | 1191237-69-0 |
| Storage | Store At Cool Dry Place |
| Molecular Weight | 291.26 |
| Boiling Point | N/A |
| Product Name | GS-441524 Powder |
| Shelf Life | 2 Years |
| Test Method | HPLC UV |
| Grade | Pharmaceutcial Grade |
| Appearance | White Powder |
GS-441524 is the main plasma metabolite of the antiviral prodrug remdesivir, and has a half-life of around 24 hours in human patients. Remdesivir and GS-441524 were both found to be effective in vitro against feline coronavirus strains responsible for feline infectious peritonitis (FIP), a lethal systemic disease affecting domestic cats.
