GS-441524 is the main plasma metabolite of the antiviral prodrug remdesivir, and has a half-life of around 24 hours in human patients. Remdesivir and GS-441524 were both found to be effective in vitro against feline coronavirus strains responsible for feline infectious peritonitis (FIP), a lethal systemic disease affecting domestic cats.
When a cat's immune system is functioning normally, white blood cells are able to fight off viruses and form antibodies to prevent it from replicating. However, cats who develop FIP are unable to do this due to an immune defect or deficiency. As a result, their white blood cells are unable to fight off the virus and allow for it to spread throughout the cat's body, leading to either wet or dry FIP.
GS441524 acts as an analog which carries out a molecular process called RNA dependent RNA polymerase. In simpler terms, this process involves GS441524 inserting itself into the chain reaction and effectively halting the virus from replicating.
| Parameter | Value |
|---|---|
| Route of Administration | Intramuscular Or Subcutaneous |
| Product Name | GS-441524 Injections |
| Form | Injections |
| Specification | 20mg/mL, 30mg/mL |
| Storage | Store At 2°C To 20°C |
| CAS | 1191237-69-0 |
| Grade | Pharmaceutcial Grade |
| Packaging | 10 Vial Per Box |
| 12 months | 12 Months |
| Active Ingredient | GS-441524 |
Recommended dosage:*DOSAGE IS BASED ON THE WEIGHT AND SYMPTOMS*
Ascites / pleural effusion: 0.5mL/kg * body weight kg + 0.1 residue
FIP(Wet):0.4mL/kg * body weight kg + 0.1 residue
FIP(Dry): 0.6mL/kg * body weight kg + 0.1 residue
Eye / nerve entry: 0.7mL/kg * body weight kg + 0.1 residue
Recurrence: 0.9 mL/ kg * body weight kg + 0.1 residue
Precautions for injection
(1) Injection method.
Subcutaneous injection, 0.3mm fine needle is recommended.
(2) Make sure your cat gets enough water.
It is very necessary for your cat to get enough water before and after the injection. If your cat is severely dehydrated, the medicine may not be fully absorbed. If you suspect that your cat may be dehydrated, ask your veterinarian for help on how to get enough fluids.
(3) Choose the right injection site.
Find a piece of loose skin. Generally speaking, the skin between the neck and back of a cat is the most loose skin.
(4) Inject medicine.
If you notice blood or medicine coming out of the injection site, use a clean cotton ball to gently press the injection site until the secretion stops.
This should only take a minute or so, but if your cat moves around too often, it may take longer.
(5) Correctly dispose of used needles.
Do not put uncovered needles in the trash can, as this may cause infection to people.
