GS-441524 is the main plasma metabolite of the antiviral prodrug remdesivir, and has a half-life of around 24 hours in human patients. Remdesivir and GS-441524 were both found to be effective in vitro against feline coronavirus strains responsible for feline infectious peritonitis (FIP), a lethal systemic disease affecting domestic cats.
If a cat’s immune system is healthy and mature, the white blood cells should fight off an infection or virus, and allow the cat to build up an immune response, or antibodies. Cats who develop FIP, however, have an immune defect or deficiency that causes the white blood cells to replicate, rather than fight, the virus. Therefore, the cats' immune system is spreading the virus throughout the cat’s body rather than trying to eliminate it. Cats who have no immune response develop wet FIP, while cats who have a partial immune response develop dry FIP.
The nucleoside analog GS441524 is a molecular precursor to a pharmacologically active nucleoside triphosphate molecule. It works as an alternative substrate and RNA-chain terminator of viral RNA dependent RNA polymerase. In simpler terms, GS441524 interjects itself into the chain reaction and stops the replication of the virus, making it an antiviral drug that is highly selective for coronavirus.
| Product Attributes | Details |
|---|---|
| Product Usage | Cat FIPV Treatment |
| Product Storage | Store In A Cool, Dry Place |
| CAS | 1191237-69-0 |
| Specification | 20mg/mL, 30mg/mL |
| Test Method | HPLC UV |
| Molecular Weight | C12H13N5O4 |
| Shipping Method | Air(UPS, FedEx, TNT, EMS) Or Sea |
| Product Form | Injections |
| Product Shelf Life | 1 Years |
| Product Packaging | 10 Vial Per Box |
| Product Name | GS441524 |
| Product Type | Remdesivir intermediate |
Recommended dosage:*DOSAGE IS BASED ON THE WEIGHT AND SYMPTOMS*
Ascites / pleural effusion: 0.5mL/kg * body weight kg + 0.1 residue
FIP(Wet):0.4mL/kg * body weight kg + 0.1 residue
FIP(Dry): 0.6mL/kg * body weight kg + 0.1 residue
Eye / nerve entry: 0.7mL/kg * body weight kg + 0.1 residue
Recurrence: 0.9 mL/ kg * body weight kg + 0.1 residue
Storage
Store at room temperature or Store at 2~4 ° C (Better). Avoid light. Shelf life is one year.
Do not place in a sub-zero environment. Because this will result in the precipitation of active ingredients and the appearance of crystals, thus affecting the concentration and therapeutic effect.
Precautions for injection
(1) Injection method.
Subcutaneous injection, 0.3mm fine needle is recommended.
(2) Make sure your cat gets enough water.
It is very necessary for your cat to get enough water before and after the injection. If your cat is severely dehydrated, the medicine may not be fully absorbed. If you suspect that your cat may be dehydrated, ask your veterinarian for help on how to get enough fluids.
(3) Choose the right injection site.
Find a piece of loose skin. Generally speaking, the skin between the neck and back of a cat is the most loose skin.
(4) Inject medicine.
If you notice blood or medicine coming out of the injection site, use a clean cotton ball to gently press the injection site until the secretion stops.
This should only take a minute or so, but if your cat moves around too often, it may take longer.
(5) Correctly dispose of used needles.
Do not put uncovered needles in the trash can, as this may cause infection to people.
