GS-441524 powder is a highly specialized form of an antiviral medication used to treat Feline Infectious Peritonitis (FIP), a serious and often fatal disease in cats caused by a mutation of the feline coronavirus. As an investigational drug, GS-441524 has shown considerable promise in clinical and practical settings for its ability to halt the progression of this previously untreatable disease.
Injectable Form: When reconstituted into an injectable solution, GS-441524 is typically administered subcutaneously. This route is particularly beneficial for cats with severe gastrointestinal symptoms, as it bypasses the digestive tract and ensures rapid systemic absorption.
Oral Suspension: Alternatively, the reconstituted powder can be given orally, either directly or mixed with food. This method is more convenient for long-term treatment, especially in a home care setting, and is often used for maintenance therapy after initial stabilization with injections.
Clinical studies and anecdotal evidence have demonstrated the efficacy of GS-441524 in treating various forms of FIP, including both the effusive (wet) and non-effusive (dry) forms. Many cats have shown significant improvement, with symptoms such as fever, weight loss, and lethargy resolving over time. In some cases, complete remission has been achieved, offering a new lease on life for cats that were once facing a grim prognosis.
| Property | Details |
|---|---|
| CAS Number | 1191237-69-0 |
| Grade | Pharmaceutcial Grade |
| Shipping Method | Air(UPS, FedEx, TNT, EMS) Or Sea |
| Density | 1.84±0.1 G |
| Appearance | White Powder |
| Storage | Store At Cool Dry Place |
| Molecular Weight | 291.26 |
| Purity |
99.0% |
Diagnosing FIP is challenging and often involves a combination of clinical signs, laboratory tests, and ruling out other diseases. Common diagnostic steps include:
1. Blood tests: Elevated protein levels, high white blood cell count, and low albumin-to-globulin ratio.
2. Imaging: Ultrasound or X-rays to detect fluid accumulation.
3. Fluid analysis: Testing the fluid from the abdomen or chest for elevated protein levels and specific cell types.
4. Biopsy: Histopathological examination of affected tissues can provide a definitive diagnosis.
GS441524 powder is a nucleoside analog that has gained significant attention for its role in antiviral research, particularly in the treatment of certain viral infections. Here are its primary functions:
1. Antiviral Action: GS441524 is primarily known for its effectiveness in inhibiting the replication of certain viruses, including coronaviruses like SARS-CoV-2. It works by interfering with the virus's RNA replication process, preventing it from multiplying within host cells.
2. Nucleoside Analog: As a nucleoside analog, GS441524 mimics the natural building blocks of RNA. When incorporated into the viral RNA during replication, it disrupts the virus's ability to produce viable RNA strands, ultimately halting viral replication.
3. Therapeutic Potential: GS441524 has shown promise as a therapeutic agent for the treatment of diseases caused by RNA viruses, such as feline infectious peritonitis (FIP) in cats, and is being researched for its potential in treating human viral infections, including COVID-19.
4. Precursor to Remdesivir: GS441524 is the primary active metabolite of remdesivir, an antiviral drug used in the treatment of COVID-19. Its function is closely related to remdesivir's mechanism of action, though GS441524 may offer distinct advantages in terms of absorption and distribution in the body.
