GS-441524 Injection Medicine Cure For Cat FIP Treatment

Product Description:

GS-441524 is a plasma metabolite of the antiviral prodrug RDV that has a half-life of 24 hours in humans. It has been found to be effective in fighting off feline coronavirus strains, responsible for the lethal disease feline infectious peritonitis (FIP), in in vitro tests.
 
FIP is caused by an immune defect or deficiency which causes white blood cells to replicate the virus as opposed to fighting it. Those cats whose immune system is not able to fight the virus, develop into wet FIP, while those who have a partial immune response develop dry FIP.
 
GS441524 is a nucleoside analog that acts as an alternative substrate and chain terminator. In simple terms, it interrupts the chain reaction of the virus, stopping its replication. This powerful nucleoside is proving to be a promising drug in combating this deadly infection in cats.
 

Technical Parameters:

What is FIP?

Feline Infectious Peritonitis (FIP) is a deadly viral disease in cats caused by a mutation of the feline coronavirus (FCoV). Although most cats infected with FCoV never develop FIP, in certain cases the virus mutates, triggering an abnormal immune response that leads to this life-threatening condition.

FCoV is particularly common in multi-cat environments, such as shelters, catteries, and households with multiple cats. The virus is primarily spread through fecal-oral transmission, occurring when cats ingest the virus from contaminated surfaces, litter boxes, or through grooming and close contact with other cats.

Applications:

1. Packing

Each box contains 10 vials of GS-441524 Injection.

2. Recommended Treatment Duration

The typical course of treatment is 12 weeks, though the exact duration may vary depending on the cat’s condition and veterinary assessment.

3. Recommended Dosage

Dosage should be calculated based on the cat’s body weight and clinical symptoms:

Ascites / Pleural Effusion: 0.5 mL/kg × body weight + 0.1 mL residual

FIP (Wet): 0.4 mL/kg × body weight + 0.1 mL residual

FIP (Dry): 0.6 mL/kg × body weight + 0.1 mL residual

Eye or Nervous System Involvement: 0.7 mL/kg × body weight + 0.1 mL residual

Recurrence: 0.9 mL/kg × body weight + 0.1 mL residual

Note: Always follow veterinary guidance when determining the exact dosage.

4. Storage Instructions

Store at room temperature, or preferably at 2–4°C, protected from light.

5. Shelf life: 1 year.

Do not store in sub-zero temperatures, as freezing may cause precipitation of active ingredients and crystal formation, which can reduce concentration and effectiveness.

Issues You Care About

【 Usage 】

Subcutaneous injection, once within 24 hours, can be injected into the neck or both sides of the back of the cat. It is recommended to switch to different areas for injection every day;

【 Dosage 】

0.4ml/kg -0.8ml/kg; Determine the dosage based on the clinical condition of the cat;

【 Preservation 】

Place in the refrigerator's freshness layer (2-4℃) and avoid direct sunlight;

【 Suggested treatment period 】

45 to 84 days, depending on the cat's re examination index and individual differences, to be determined by the doctor and owner through consultation;

【 Precautions 】

1. When injecting the injection, be careful not to hit the superficial cortex. If hit on the superficial cortex, the cat is prone to bulging, and the leakage of the medication may cause some irritation to the cat's skin; ① If any liquid medicine leaks out of the skin, it should be promptly wiped and cleaned; ② If bulging occurs, a hot towel can be applied to the bulging area for 5-10 minutes;

2. Because FIP cats generally have severe inflammation, anemia, liver, and kidney damage, during treatment, according to the reported index of cat examination, it is recommended to add corresponding auxiliary drugs, such as liver protection tablets, anti-inflammatory tablets, kidney tonics, and blood tonics;

3. Each cat has different levels of drug absorption, and generally after 3-5 days of injection treatment, the cat begins to gradually improve; If the cat still does not improve after 7-10 days of injection treatment, the owner needs to take the cat to the hospital for examination in a timely manner, and consider whether the cat is suffering from other diseases, or if the cat has cat to cat transmission and other diseases occur simultaneously;

4. This injection only treats FIP and has no therapeutic effect on other diseases. If the cat also suffers from other diseases while suffering from FIP, other diseases also need to be treated together with medication;

5. There are roughly two types of FIP:

① wet cat transmission - there is fluid accumulation in the body. If the fluid accumulation does not affect the cat's breathing, it is not recommended to remove it. After treatment, the fluid accumulation will slowly absorb and be discharged;

② Dry cat transmission - there is no fluid accumulation in the body, which is generally difficult to detect in the early stage. Viral transmission is generally stronger, so it is generally more difficult to treat compared to wet transmission. During treatment, it is recommended to use a larger amount of medication. If the virus invades the nerves and limbs, treatment may be delayed, and a small number of cat limbs may not be able to recover to their pre disease state;