GS-441524 is a plasma metabolite of the antiviral prodrug remdesivir, and it has a recorded half-life of around 24 hours in human patients.
Both remdesivir and GS-441524 were discovered to be effective in inhibiting feline coronavirus strains that were responsible for causing feline infectious peritonitis (FIP), a fatal systemic disease that commonly affects domestic cats.
When a cat has a healthy immune system, white blood cells can be mobilized to combat viruses and form antibodies so that the virus is unable to replicate further. Unfortunately, cats with FIP do not have this option due to an immune defect or deficiency that weakens their white blood cells' defense fight against the virus and allows for it to spread throughout the cat's body, leading them to either wet or dry FIP.
| Parameters | Details |
|---|---|
| Product Name | GS-441524 Vials |
| Grade | Pharmaceutcial Grade |
| Strength | 20mg/ml |
| CAS | 1191237-69-0 |
| Route of Administration | Subcutaneous |
| Specification | 6ml/vial |
| Storage | Store At 2°C To 20°C |
| Packaging | 10 Vials/Box |
| Shipping Method | Air(UPS, FedEx, TNT, EMS) |
| Expiration Date | 12 Months |
The recommended treatment is 12 weeks.
The recommended dosage is based on the weight and symptoms of the patient.
For ascites or pleural effusion, the dosage is 0.5mL/kg * body weight kg + 0.1 residue.
For FIP (wet), the dosage is 0.4mL/kg * body weight kg + 0.1 residue.
For FIP (dry), the dosage is 0.6mL/kg * body weight kg + 0.1 residue.
For eye or nerve entry, the dosage is 0.7mL/kg * body weight kg + 0.1 residue.
And for recurrence, the dosage is 0.9mL/kg * body weight kg + 0.1 residue.
The medication should be stored at room temperature or at 2~4 ° C (better). Exposure to light should be avoided. The shelf life of the medication is one year. It must not be placed in a sub-zero environment or else it will result in the precipitation of active ingredients and the appearance of crystals, which will affect its concentration and therapeutic effect.
