GS-441524 is the main plasma metabolite of the antiviral prodrug remdesivir, and has a half-life of around 24 hours in human patients. Remdesivir and GS-441524 have both demonstrated effectiveness in vitro against feline coronavirus strains related to feline infectious peritonitis (FIP), a lethal systemic disease affecting domestic cats.
When a cat's immune system is in good health, white blood cells are able to defend against viruses and create antibodies to prevent their propagation. Unfortunately, FIP disables this functionality since the immune system is either compromised or limited.
Consequently, the white blood cells are unable to combat the virus or prevent it from becoming systemic, leading to one of two varieties of the disease: wet FIP or dry FIP.
GS441524 acts as an analog which executes a molecular process called RNA dependent RNA polymerase. This process is simplified as GS441524 inserting itself into the chain reaction and impeding the virus from replicating.
Recommended treatment: 12 weeks.
Recommended dosage:*DOSAGE IS BASED ON THE WEIGHT AND SYMPTOMS*
Ascites / pleural effusion: 0.5mL/kg * body weight kg + 0.1 residue
FIP(Wet):0.4mL/kg * body weight kg + 0.1 residue
FIP(Dry): 0.6mL/kg * body weight kg + 0.1 residue
Eye / nerve entry: 0.7mL/kg * body weight kg + 0.1 residue
Recurrence: 0.9 mL/ kg * body weight kg + 0.1 residue
Storage
Store at room temperature or Store at 2~4 ° C (Better). Avoid light. Shelf life is one year.
Do not place in a sub-zero environment. Because this will result in the precipitation of active ingredients and the appearance of crystals, thus affecting the concentration and therapeutic effect.
