GS-441524 is a key component in the antiviral prodrug remdesivir which has a half-life of around 24 hours in humans. It is a potent inhibitor of feline coronavirus strains responsible for feline infectious peritonitis (FIP), a potentially fatal systemic illness impacting cats.
A functioning immune system is able to combat viral agents and form antibodies in order to limit reproduction. However, cats with FIP are unable to do this due to an impaired or deficient defence system. Consequently, white blood cells are unable to restrain the spread of the virus, resulting in either wet or dry FIP.
GS-441524 works through a molecular process known as RNA dependent RNA polymerase. Basically, this method has GS441524 interjecting itself into the chain reaction and restraining the virus from reproducing. Even if exposed to high concentrations of the virus, replication is curbed in the presence of GS441524 at the infection point. Thus, when administering remdesivir and GS-441524 to infected cats, the virus is brought under control and unable to reproduce.
FIP(Wet): 0.3ml/kg * body weight kg + 0.1ml residue
FIP (Dry): 0.4ml/kg * body weight kg + 0.1ml residue
Eye / nerve entry: 0.5ml/kg * body weight kg + 0.1ml residue
Recurrence: 0.6 ml / kg * body weight kg + 0.1ml residue
For example, if your cat is 3kg and wet FIP, the dosage is 0.3ml/kg * 3 kg + 0.1ml residue=1.0ml per time per day.
As the treatment progresses, the weight of the cat will gradually increase. It is recommended to measure the weight several times a week and adjust the dosage in time.
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