GS-441524 is the main plasma metabolite of the antiviral prodrug remdesivir, and has a half-life of around 24 hours in human patients. Remdesivir and GS-441524 were both found to be effective in vitro against feline coronavirus strains responsible for feline infectious peritonitis (FIP), a lethal systemic disease affecting domestic cats.
How GS441524 Cures FIP
If a cat's immune system is healthy and mature, the white blood cells should fight off an infection or virus, and allow the cat to build up an immune response, or antibodies. Cats who develop FIP have an immune defect or deficiency that causes the white blood cells to replicate, rather than fight, the virus. Essentially, the cats immune system is spreading the virus throughout the cat's body rather than trying to eliminate it. Cats who have no immune response develop wet FIP, while cats who have a partial immune response develop dry FIP.
The nucleoside analog GS441524 is a molecular precursor to a pharmacologically active nucleoside triphosphate molecule. These analogs act as an alternative substrate and RNA-chain terminator of viral RNA dependent RNA polymerase. In layman's terms, GS441524 interjects itself into the chain reaction and stops the replication of the virus.
GS-441524 is the main plasma metabolite of the antiviral prodrug remdesivir, and has a half-life of around 24 hours in human patients. Remdesivir and GS-441524 were both found to be effective in vitro against feline coronavirus strains responsible for feline infectious peritonitis (FIP), a lethal systemic disease affecting domestic cats.
How long is the treatment?
The recommended duration of treatment is 12 weeks. However, the actual duration of treatment may depend on many factors such as how quickly your cat responds to treatment, the degree of FIP infection when you start treatment, and your personal financial condition.
Can GS-441524 be used in combination with other drugs?
Yes, GS is an antiviral treatment, and can be used in conjunction with other medications to improve your cat's overall health. However, Lysine is not recommended for use in conjunction with GS. Fluoroquinolone class of antibiotics and flea treatments should be avoided during FIP treatment. Interferon has no effect on the treatment of FIP virus.
What should I feed my cat during FIP treatment?
Freshly cooked fish, poultry and natural foods. If your cat has diarrheas, consider switching to dry cat food for a few days until the diarrheas stops.
