GS-441524 is the main plasma metabolite of the antiviral prodrug remdesivir, and has a half-life of around 24 hours in human patients. Remdesivir and GS-441524 were both found to be effective in vitro against feline coronavirus strains responsible for feline infectious peritonitis (FIP), a lethal systemic disease affecting domestic cats.
Cats with healthy and mature immune system are able to fight off a virus and build up an immune response, or antibodies. However, cats who suffer from FIP have an immune system that is not capable of fighting the virus, instead it spreads the virus throughout the body. Cats who have no immune response develop wet FIP, while cats with a partial immune response develop dry FIP.
The nucleoside analog GS441524 is a precursor to an active nucleoside triphosphate molecule, that acts as a substitution to the infectious virus. It injects itself into the chain reaction and stops the virus from replicating. Studies have shown that cats who were infected with FIP, and were given GS441524, had a decreased virus load, as well as a regression of clinical signs.
| Keyword | Description |
|---|---|
| CAS | 1191237-69-0 |
| Active Ingredient | GS-441524 |
| Route of Administration | Intramuscular Or Subcutaneous |
| Shipping Method | Air (UPS, FedEx, TNT, EMS) Or Sea |
| Form | Injections |
| Grade | Pharmaceutcial Grade |
| Specification | 20mg/mL, 30mg/mL |
| Storage | Store At 2°C To 20°C |
| Packaging | 10 Vial Per Box |
Recommended dosage:*DOSAGE IS BASED ON THE WEIGHT AND SYMPTOMS*
Ascites / pleural effusion: 0.5mL/kg * body weight kg + 0.1 residue
FIP(Wet):0.4mL/kg * body weight kg + 0.1 residue
FIP(Dry): 0.6mL/kg * body weight kg + 0.1 residue
Eye / nerve entry: 0.7mL/kg * body weight kg + 0.1 residue
Recurrence: 0.9 mL/ kg * body weight kg + 0.1 residue
Precautions for injection
(1) Injection method.
Subcutaneous injection, 0.3mm fine needle is recommended.
(2) Make sure your cat gets enough water.
It is very necessary for your cat to get enough water before and after the injection. If your cat is severely dehydrated, the medicine may not be fully absorbed. If you suspect that your cat may be dehydrated, ask your veterinarian for help on how to get enough fluids.
(3) Choose the right injection site.
Find a piece of loose skin. Generally speaking, the skin between the neck and back of a cat is the most loose skin.
(4) Inject medicine.
If you notice blood or medicine coming out of the injection site, use a clean cotton ball to gently press the injection site until the secretion stops.
This should only take a minute or so, but if your cat moves around too often, it may take longer.
(5) Correctly dispose of used needles.
Do not put uncovered needles in the trash can, as this may cause infection to people.
