GS441524 Liquid Form For Easy Administration In Cats

Product Description:

GS-441524 liquid form is an antiviral medication used in the treatment of Feline Infectious Peritonitis (FIP), a fatal disease in cats caused by a mutation of the feline coronavirus. This liquid formulation is particularly useful for precise dosing, allowing veterinarians to tailor the dosage to a cat's specific needs based on weight and severity of the disease. GS-441524, a nucleoside analog, works by inhibiting the replication of the virus, thereby reducing viral load and helping the cat's immune system to fight the infection. The liquid form is advantageous for cats that have difficulty swallowing tablets or require frequent adjustments in their medication dosage. It is typically administered orally, and despite the lack of official approval in many regions, it has become a vital treatment option for managing FIP, offering hope for recovery where few other options exist.

Technical Parameters:

What is FIP?

Feline Infectious Peritonitis (FIP) is a severe and often fatal disease in cats, caused by a mutation of the feline coronavirus. This mutation leads to an abnormal immune response, which causes widespread inflammation in various organs. FIP primarily affects young cats, although it can occur at any age, and is more common in multi-cat environments, such as shelters or catteries.

There are two main forms of FIP: effusive (wet) and non-effusive (dry). The wet form is characterized by the accumulation of fluid in the abdomen or chest, leading to symptoms like distended abdomen, difficulty breathing, and lethargy. The dry form does not involve fluid accumulation but causes inflammatory lesions in organs such as the liver, kidneys, spleen, and central nervous system. Cats with the dry form may exhibit neurological symptoms, jaundice, or ocular changes.

Diagnosis of FIP

Diagnosing FIP is challenging and often involves a combination of clinical signs, laboratory tests, and ruling out other diseases. Common diagnostic steps include:

1. Blood tests: Elevated protein levels, high white blood cell count, and low albumin-to-globulin ratio.

2. Imaging: Ultrasound or X-rays to detect fluid accumulation.

3. Fluid analysis: Testing the fluid from the abdomen or chest for elevated protein levels and specific cell types.

4. Biopsy: Histopathological examination of affected tissues can provide a definitive diagnosis.

Applications:

Packing: 1 box * 10 vials
 
Recommended treatment: 12 weeks.
 
Recommended dosage:*DOSAGE IS BASED ON THE WEIGHT AND SYMPTOMS*
Ascites / pleural effusion: 0.5mL/kg * body weight kg + 0.1 residue
FIP(Wet):0.4mL/kg * body weight kg + 0.1 residue
FIP(Dry): 0.6mL/kg * body weight kg + 0.1 residue
Eye / nerve entry: 0.7mL/kg * body weight kg + 0.1 residue
Recurrence: 0.9 mL/ kg * body weight kg + 0.1 residue
 
Storage
 
Store at room temperature or Store at 2~4 ° C (Better). Avoid light. Shelf life is one year.
 
Do not place in a sub-zero environment. Because this will result in the precipitation of active ingredients and the appearance of crystals, thus affecting the concentration and therapeutic effect.

Issues You Care About

【 Usage 】

Subcutaneous injection, once within 24 hours, can be injected into the neck or both sides of the back of the cat. It is recommended to switch to different areas for injection every day;

【 Dosage 】

0.4ml/kg -0.8ml/kg; Determine the dosage based on the clinical condition of the cat;

【 Preservation 】

Place in the refrigerator's freshness layer (2-4℃) and avoid direct sunlight;

【 Suggested treatment period 】

45 to 84 days, depending on the cat's re examination index and individual differences, to be determined by the doctor and owner through consultation;

【 Precautions 】

1. When injecting the injection, be careful not to hit the superficial cortex. If hit on the superficial cortex, the cat is prone to bulging, and the leakage of the medication may cause some irritation to the cat's skin; ① If any liquid medicine leaks out of the skin, it should be promptly wiped and cleaned; ② If bulging occurs, a hot towel can be applied to the bulging area for 5-10 minutes;

2. Because FIP cats generally have severe inflammation, anemia, liver, and kidney damage, during treatment, according to the reported index of cat examination, it is recommended to add corresponding auxiliary drugs, such as liver protection tablets, anti-inflammatory tablets, kidney tonics, and blood tonics;

3. Each cat has different levels of drug absorption, and generally after 3-5 days of injection treatment, the cat begins to gradually improve; If the cat still does not improve after 7-10 days of injection treatment, the owner needs to take the cat to the hospital for examination in a timely manner, and consider whether the cat is suffering from other diseases, or if the cat has cat to cat transmission and other diseases occur simultaneously;

4. This injection only treats FIP and has no therapeutic effect on other diseases. If the cat also suffers from other diseases while suffering from FIP, other diseases also need to be treated together with medication;

5. There are roughly two types of FIP:

① wet cat transmission - there is fluid accumulation in the body. If the fluid accumulation does not affect the cat's breathing, it is not recommended to remove it. After treatment, the fluid accumulation will slowly absorb and be discharged;

② Dry cat transmission - there is no fluid accumulation in the body, which is generally difficult to detect in the early stage. Viral transmission is generally stronger, so it is generally more difficult to treat compared to wet transmission. During treatment, it is recommended to use a larger amount of medication. If the virus invades the nerves and limbs, treatment may be delayed, and a small number of cat limbs may not be able to recover to their pre disease state;

6. Duration of FIP treatment:

① It is recommended that the duration of cat abdominal transmission should be at least 45 days, but this time is not fixed. It is required that under the premise of normal other indicators, the white cell ratio should be higher than 0.7 (which is the most important indicator);

② The experimental theory is continuous injection therapy for 12 weeks, which is a recommended course of treatment given by researchers through continuous exploration: it may not be suitable for all cats, but it must be suitable for most cats; If the injection stops for a short period of treatment and relapses, the dosage needs to be doubled, the cost is more expensive, and cats are also very painful. Therefore, if economic conditions allow, the closer the injection treatment is to 12 weeks, the lower the recurrence rate of cats; ③ Suggestion for stopping injection: All blood routine indicators are normal, lymphocyte percentage is normal, biochemical indicators are all normal, and globulin is within the normal range.