GS-441524 is the main plasma metabolite of the antiviral prodrug remdesivir, and has a half-life of around 24 hours in human patients. Remdesivir and GS-441524 were both found to be effective in vitro against feline coronavirus strains responsible for feline infectious peritonitis (FIP), a lethal systemic disease affecting domestic cats.
| Property | Details |
|---|---|
| CAS Number | 1191237-69-0 |
| Grade | Pharmaceutcial Grade |
| Shipping Method | Air(UPS, FedEx, TNT, EMS) Or Sea |
| Density | 1.84±0.1 G |
| Appearance | White Powder |
| Storage | Store At Cool Dry Place |
| Molecular Weight | 291.26 |
| Purity |
99.0% |
FIP, or Feline Infectious Peritonitis, is a viral disease caused by a strain of the feline coronavirus. Here’s a brief overview:
1. Causative Agent: FIP is caused by a mutated form of the feline coronavirus (FCoV). While FCoV is common and usually causes mild gastrointestinal symptoms, in some cats, the virus mutates into the more deadly form that causes FIP.
2. Transmission: FCoV is spread through fecal-oral transmission, meaning cats can become infected by ingesting the virus from contaminated litter boxes, food, or water. FIP itself is not directly contagious; it is the benign form of the virus that spreads between cats.
3. Symptoms: There are two forms of FIP:
Wet (Effusive) Form: Characterized by fluid accumulation in the abdomen or chest, leading to a swollen belly or difficulty breathing.
Dry (Non-effusive) Form: Characterized by granulomas (clusters of immune cells) forming in various organs, leading to more varied symptoms like weight loss, fever, jaundice, and neurological signs.
4. Diagnosis: Diagnosing FIP is challenging due to the lack of a single definitive test. Veterinarians typically use a combination of clinical signs, blood tests, imaging studies, and sometimes biopsies.
5. Treatment: Historically, FIP was considered fatal. However, recent developments in antiviral drugs, like GS-441524 (an analog of Remdesivir), have shown promise in treating the disease.
6. Prevention: Reducing the risk of FCoV infection involves maintaining good hygiene, reducing stress in multi-cat households, and ensuring good litter box practices. There is no fully effective vaccine for FIP currently available.
GS441524 is a medication used to treat feline infectious peritonitis (FIP). Below are the general guidelines for using GS441524 powder, but specific usage should be adjusted according to a veterinarian's instructions:
1. Dosage:
The typical dosage depends on the cat's weight and the severity of the condition. The recommended dosage is usually 4-6 mg/kg of body weight, but higher doses may be required for severe cases.
2. Preparation:
GS441524 powder needs to be dissolved in sterile water or another appropriate solvent. Preparation should be done in a clean, sterile environment to ensure the stability and effectiveness of the medication.
3. Injection:
The dissolved solution is usually administered via subcutaneous or intravenous injection. For subcutaneous injection, choose a soft skin area (such as the back or shoulder) and use a sterile syringe. Intravenous injection should be performed by a professional veterinarian.
4. Frequency and Duration:
Generally, the injection is given once daily for at least 12 weeks. During the treatment, regular blood tests and other diagnostic evaluations are necessary to monitor the treatment's effectiveness and adjust the dosage as needed.
5. Precautions:
Ensure all equipment (syringes, solvents, etc.) is sterile.
Avoid overdosing to prevent potential toxicity and side effects.
If any adverse reactions occur during treatment, contact a veterinarian immediately.
The specific method and dosage should be determined and adjusted by a veterinarian based on the cat's condition. Always consult a professional veterinarian and follow their instructions precisely when using GS441524 powder.
