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Factory supply GS-441524 to Treat FIP in Cats

10 vials
MOQ
US$20-US$30
Price
Factory supply GS-441524 to Treat FIP in Cats
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Features
Specifications
Molecular Weight: C12H13N5O4
Product Name: GS441 FIP Treatment
Specification: 20mg/mL, 30mg/mL
Product Packaging: 10 Vial Per Box
Shipping Method: Air(UPS, FedEx, TNT, EMS) Or Sea
Test Method: HPLC UV
Product Type: Liquid
Product Usage: Cat FIPV Treatment
Active Ingredient: GS-441524
Form: Injections
Grade: Pharmaceutcial Grade
CAS: 1191237-69-0
Basic Infomation
Place of Origin: China
Brand Name: FIPNOPE
Payment & Shipping Terms
Packaging Details: 10 vial per box
Delivery Time: 2-3 days
Payment Terms: Western Union, T/T, MoneyGram, Paypal
Supply Ability: 100000 vials per month
Product Description

Product Description:

GS-441524 is a plasma metabolite of the antiviral prodrug remdesivir that has a half-life of 24 hours in humans. It has been found to be effective in fighting off feline coronavirus strains, responsible for the lethal disease feline infectious peritonitis (FIP), in in vitro tests.
 
FIP is caused by an immune defect or deficiency which causes white blood cells to replicate the virus as opposed to fighting it. Those cats whose immune system is not able to fight the virus, develop into wet FIP, while those who have a partial immune response develop dry FIP.
 
GS441524 is a nucleoside analog that acts as an alternative substrate and chain terminator. In simple terms, it interrupts the chain reaction of the virus, stopping its replication. This powerful nucleoside is proving to be a promising drug in combating this deadly infection in cats.
 

Technical Parameters:

Parameter Value
Specification 20mg/mL, 30mg/mL
Product Shelf Life 1 Year
Product Form Injections
Product Packaging 10 Vial Per Box
Shipping Method Air(UPS, FedEx, TNT, EMS) Or Sea
Product Usage Cat FIPV Treatment
Product Type Liquid
Test Method HPLC UV
Molecular Weight C12H13N5O4
Product Storage Store In A Cool, Dry Place
Product Name GS441 FIP Treatment
Product Characteristics Cat FIP, Remdesivir intermediate

 

What is FIP?

FIP, or Feline Infectious Peritonitis, is a viral disease caused by a strain of the feline coronavirus. Here’s a brief overview:

 

1. Causative Agent: FIP is caused by a mutated form of the feline coronavirus (FCoV). While FCoV is common and usually causes mild gastrointestinal symptoms, in some cats, the virus mutates into the more deadly form that causes FIP.

 

2. Transmission: FCoV is spread through fecal-oral transmission, meaning cats can become infected by ingesting the virus from contaminated litter boxes, food, or water. FIP itself is not directly contagious; it is the benign form of the virus that spreads between cats.

 

3. Symptoms: There are two forms of FIP:

  • Wet (Effusive) Form: Characterized by fluid accumulation in the abdomen or chest, leading to a swollen belly or difficulty breathing.
  • Dry (Non-effusive) Form: Characterized by granulomas (clusters of immune cells) forming in various organs, leading to more varied symptoms like weight loss, fever, jaundice, and neurological signs.

 

4. Diagnosis: Diagnosing FIP is challenging due to the lack of a single definitive test. Veterinarians typically use a combination of clinical signs, blood tests, imaging studies, and sometimes biopsies.

 

5. Treatment: Historically, FIP was considered fatal. However, recent developments in antiviral drugs, like GS-441524 (an analog of Remdesivir), have shown promise in treating the disease.

 

6. Prevention: Reducing the risk of FCoV infection involves maintaining good hygiene, reducing stress in multi-cat households, and ensuring good litter box practices. There is no fully effective vaccine for FIP currently available.

 

Applications:

Packing: 1 box * 10 vials
 
Recommended treatment: 12 weeks.
 
Recommended dosage:*DOSAGE IS BASED ON THE WEIGHT AND SYMPTOMS*
Ascites / pleural effusion: 0.5mL/kg * body weight kg + 0.1 residue
FIP(Wet):0.4mL/kg * body weight kg + 0.1 residue
FIP(Dry): 0.6mL/kg * body weight kg + 0.1 residue
Eye / nerve entry: 0.7mL/kg * body weight kg + 0.1 residue
Recurrence: 0.9 mL/ kg * body weight kg + 0.1 residue

 
Storage
 
Store at room temperature or Store at 2~4 ° C (Better). Avoid light. Shelf life is one year.
 
Do not place in a sub-zero environment. Because this will result in the precipitation of active ingredients and the appearance of crystals, thus affecting the concentration and therapeutic effect.

 

Issues You Care About

【 Usage 】

 

Subcutaneous injection, once within 24 hours, can be injected into the neck or both sides of the back of the cat. It is recommended to switch to different areas for injection every day;

 

【 Dosage 】

 

0.4ml/kg -0.8ml/kg; Determine the dosage based on the clinical condition of the cat;

 

【 Preservation 】

 

Place in the refrigerator's freshness layer (2-4℃) and avoid direct sunlight;

 

【 Suggested treatment period 】

 

45 to 84 days, depending on the cat's re examination index and individual differences, to be determined by the doctor and owner through consultation;

 

【 Precautions 】

 

1. When injecting the injection, be careful not to hit the superficial cortex. If hit on the superficial cortex, the cat is prone to bulging, and the leakage of the medication may cause some irritation to the cat's skin; ① If any liquid medicine leaks out of the skin, it should be promptly wiped and cleaned; ② If bulging occurs, a hot towel can be applied to the bulging area for 5-10 minutes;

 

2. Because FIP cats generally have severe inflammation, anemia, liver, and kidney damage, during treatment, according to the reported index of cat examination, it is recommended to add corresponding auxiliary drugs, such as liver protection tablets, anti-inflammatory tablets, kidney tonics, and blood tonics;

 

3. Each cat has different levels of drug absorption, and generally after 3-5 days of injection treatment, the cat begins to gradually improve; If the cat still does not improve after 7-10 days of injection treatment, the owner needs to take the cat to the hospital for examination in a timely manner, and consider whether the cat is suffering from other diseases, or if the cat has cat to cat transmission and other diseases occur simultaneously;

 

4. This injection only treats FIP and has no therapeutic effect on other diseases. If the cat also suffers from other diseases while suffering from FIP, other diseases also need to be treated together with medication;

 

5. There are roughly two types of FIP:

① wet cat transmission - there is fluid accumulation in the body. If the fluid accumulation does not affect the cat's breathing, it is not recommended to remove it. After treatment, the fluid accumulation will slowly absorb and be discharged;

② Dry cat transmission - there is no fluid accumulation in the body, which is generally difficult to detect in the early stage. Viral transmission is generally stronger, so it is generally more difficult to treat compared to wet transmission. During treatment, it is recommended to use a larger amount of medication. If the virus invades the nerves and limbs, treatment may be delayed, and a small number of cat limbs may not be able to recover to their pre disease state;

 

6. Duration of FIP treatment:

① It is recommended that the duration of cat abdominal transmission should be at least 45 days, but this time is not fixed. It is required that under the premise of normal other indicators, the white cell ratio should be higher than 0.7 (which is the most important indicator);

② The experimental theory is continuous injection therapy for 12 weeks, which is a recommended course of treatment given by researchers through continuous exploration: it may not be suitable for all cats, but it must be suitable for most cats; If the injection stops for a short period of treatment and relapses, the dosage needs to be doubled, the cost is more expensive, and cats are also very painful. Therefore, if economic conditions allow, the closer the injection treatment is to 12 weeks, the lower the recurrence rate of cats; ③ Suggestion for stopping injection: All blood routine indicators are normal, lymphocyte percentage is normal, biochemical indicators are all normal, and globulin is within the normal range.

 
Factory supply GS-441524 to Treat FIP in Cats 0 

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