Remdesivir (RDV) is the handiest US Food and Drug Administration (FDA)-permitted drug for treating COVID-19. However, RDV can handiest accept with the aid of using intravenous route, and there may be a urgent scientific want for oral antivirals. Significant proof shows that the function of the determine nucleoside GS-441524 withinside the medical consequences of RDV will be in large part underestimated. We accomplished an in vitro and in vivo drug metabolism and pharmacokinetics (DMPK) evaluation to look at the capability of RDV, and mainly GS-441524, as oral drugs. In similarly in vivo research in CD-1 mice, GS-441524 displayed a positive oral bioavailability of 57%. Importantly, GS-441524 produced good enough drug publicity withinside the mice plasma and lung, and changed into correctly transformed to the energetic triphosphate, suggesting that it can be a promising oral antiviral drug for treating COVID-19.
| Property | Value |
|---|---|
| CAS Number | 1191237-69-0 |
| Purity | 99.0% |
| Density | 1.84±0.1 G |
| Shipping Method | Air(UPS, FedEx, TNT, EMS) Or Sea |
| Storage | Store At Cool Dry Place |
| Appearance | White Powder |
| Function | Cat FIPV Treatment |
| Molecular Formula | C12H13N5O4 |
| Test Method | HPLC UV |
| Product Name | GS-441524 Powder |
Brand Name: FIPNOPE
Place of Origin: China
Minimum Order Quantity: 10 grams
Price: Negotiable
Packaging Details: Aluminum Foil Bag/Drum
Delivery Time: 2-3 days
Payment Terms: Western Union, T/T, MoneyGram, Paypal
Supply Ability: 1000KG per month
CAS Number: 1191237-69-0
Function: Cat FIPV Treatment
Purity: 99.0%
Shelf Life: 2 Years
Shipping Method: Air(UPS, FedEx, TNT, EMS) Or Sea
How long is the treatment?
The recommended duration of treatment is 12 weeks. However, the actual duration of treatment may depend on many factors such as how quickly your cat responds to treatment, the degree of FIP infection when you start treatment, and your personal financial condition.
Can GS-441524 be used in combination with other drugs?
Yes, GS is an antiviral treatment, and can be used in conjunction with other medications to improve your cat's overall health. However, Lysine is not recommended for use in conjunction with GS. Fluoroquinolone class of antibiotics and flea treatments should be avoided during FIP treatment. Interferon has no effect on the treatment of FIP virus.
What should I feed my cat during FIP treatment?
Freshly cooked fish, poultry and natural foods. If your cat has diarrheas, consider switching to dry cat food for a few days until the diarrheas stops.
