GS-441524 is the main plasma metabolite of the antiviral prodrug remdesivir, and has a half-life of around 24 hours in human patients. Remdesivir and GS-441524 were both found to be effective in vitro against feline coronavirus strains responsible for feline infectious peritonitis (FIP), a lethal systemic disease affecting domestic cats.
How GS441524 Cures FIP
If a cat's immune system is healthy and mature, the white blood cells should fight off an infection or virus, and allow the cat to build up an immune response, or antibodies. Cats who develop FIP have an immune defect or deficiency that causes the white blood cells to replicate, rather than fight, the virus. Essentially, the cats immune system is spreading the virus throughout the cat's body rather than trying to eliminate it. Cats who have no immune response develop wet FIP, while cats who have a partial immune response develop dry FIP.
The nucleoside analog GS441524 is a molecular precursor to a pharmacologically active nucleoside triphosphate molecule. These analogs act as an alternative substrate and RNA-chain terminator of viral RNA dependent RNA polymerase. In layman's terms, GS441524 interjects itself into the chain reaction and stops the replication of the virus.
| Attributes | Details |
|---|---|
| Molecular Weight | 291.26 |
| Grade | Pharmaceutcial Grade |
| Density | 1.84±0.1 G |
| Appearance | White Powder |
| Shelf Life | 2 Years |
| Purity | 99.0% |
| Storage | Store At Cool Dry Place |
| Boiling Point | N/A |
| Shipping Method | Air(UPS, FedEx, TNT, EMS) Or Sea |
| CAS Number | 1191237-69-0 |
